Cap Score Liver - What Does Mean By Cap Score In Fibroscan Of | Practo Mansour, A., Motamed, S., Hekmatdoost, A. et al. In summary, we believe the FAST score will allow for the more efficient identification of an at-risk group of patients with progressive NASH that merit consideration for further treatment. Please do not write your name or any personal information on this feedback form. W-KC reports personal fees from Boehringer Ingelheim, Echosens, and Mylan; grants from Sysmex and Resonance Health; and non-financial support from Endosurgery, outside the submitted work. PubMed Unauthorized use of these marks is strictly prohibited. J. Obes. 9(1), 2635 (2020). Fibroscan results? - Liver disease MathSciNet Snodgrass, J. J. et al. World J Gastroenterol. /Creator ( w k h t m l t o p d f 0 . The enzyme-linked immunosorbent assay (ELISA) kit (Roche, Germany) was used to measure the serum concentration of liver enzymes, creatinine, high-sensitive C-reactive protein (hs-CRP) and lipids. 2020 Nov;5(11):970-985. doi: 10.1016/S2468-1253(20)30252-1. Sampath Kumar, A. et al. Read across the row from left to right until you find the range that includes your fibrosis result. It measures fibrosis (scarring) and steatosis (fatty change) in your liver. [2] The table below, adopted from MSK, considers different scores in the context of different liver diseases and can be used to help determine fibrosis score. PubMed Central Bookshelf At given FAST score cutoffs, it is possible to graphically assess the screen failure rate and missed cases rate together with the proportion of patients above the FAST score who would be given liver biopsy in the context of patients screening in drug trials for NASH. Non-invasive means nothing is put inside your body. 73 to 1 using the dual cutoffs approach, with cutoffs derived in the derivation cohort. /F9 9 0 R Correspondence to S. et al. JB reports personal fees from Echosens outside the submitted work. Today, in most studies, as well as in clinical practice, resting energy expenditure (REE), also known as resting metabolic rate (RMR), is used as an estimate of BMR, because it requires less restrictive conditions18,20. Liver Int. A p-value<0.05 was considered statistically significant. After overnight fasting, intravenous blood was drawn to measure enzymes and biomarkers. There is a silent epidemic of fatty liver disease in the general population, called NAFLD/NASH. CAS Your healthcare provider will use your CAP score to find out your steatosis grade. Methods: Nat. Then, look at the top of that column to see the fibrosis score.[3]. Rep. 5(6), 513520 (2003). Publication Arslanow et al. Pannacciulli, N. et al. According to the results of multivariable logistic regression analysis (Table 2), hypermetabolism was positively associated with adiponectin (odds ratio [OR] 1.17, 95% confidence interval [CI] 1.021.34, p=0.030), physical activity (OR 1.13, 95% CI 1.0021.28, p=0.046), ALT (OR 1.06, 95% CI 1.0061.12, p=0.031) and diastolic blood pressure (OR 1.07, 95% CI 1.011.13, p=0.021). Nutr. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. CAS Prevalence of NASH+NAS4+F2=57%. Article Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. [0 /XYZ 35.2500000 /Font << Bookshelf J. Clin. It ranges from 100 to 400 dB/m. Changes in protein turnover and resting energy expenditure after treatment of malaria in Gambian children. 3@kJBOxxnV1zC Oxygen species in the microvascular environment: Regulation of vascular tone and the development of hypertension. Effects of anti-diabetic treatments in type 2 diabetes and fatty liver disease. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Both LSM by VCTEand CAP are measured simultaneously without lengthening the examination time. Get the latest news and updates on MSKs cancer care and research breakthroughs sent straight to your inbox with our e-newsletters. Fatty Liver Foundation copyright 2023 all rights reserved. At a cut-off of 283 dB/m, the CAP was 76% sensitive, 79% specific, and had positive and negative predictive values of 87% and 64%, respectively. The main causes of fatty liver disease are excessive alcohol consumption and/or poor diet and sedentary lifestyle. 75(4), 18471853 (1993). Mishra S, Bhujade H, Butt AS, Kamani L, Premkumar M. Euroasian J Hepatogastroenterol. 2019 May;156(6):1717-1730. doi: 10.1053/j.gastro.2019.01.042. We found that the higher level of ALT was an independent factor predicting hypermetabolism in T2DM individuals with NAFLD. See this image and copyright information in PMC. Arrese, M. & Barrera, F. Concurrent nonalcoholic fatty liver disease and type 2 diabetes: Diagnostic and therapeutic considerations. /Annots 15 0 R A FibroScan is usually ordered for patients with medical conditions that can affect liver health, such as hepatitis B, hepatitis C, type 2 diabetes, and obesity. The ultrasound waves move at different speeds through normal liver tissue and areas of fibrosis. A FibroScan is a non-invasive diagnostic tool used to assess the health of your liver. FibroScan with CAP for fatty liver disease assessment - Echosens J. Clin. Loos, R. J. et al. BMC Sports Sci. They did the fibroscan because 6 months ago I had an ultrasound that showed a slightly enlarged spleen and some fatty infiltration in the liver. CAP performance was not influenced by measurement variability, but was higher in patients with mild (F0-F1) fibrosis (AUROC 0.89 vs. 0.72 with F2-F4; P = 0.03). livers can have up to 5% of fatty changes in them. Sayed Mahmoud Sajjadi-Jazi. /Resources 14 0 R Read across the row from left to right until you find the range that includes your fibrosis result. Int. Qi, Y. et al. (C) Sensitivity, specificity, positive predictive value, and negative predictive value versus all possible FAST score values. The elasticity modulus of liver in fatty liver rabbits of nonalcoholic and alcoholic groups showed a positive correlation with progression of liver fibrosis (P<0.01). Am. Resting energy expenditure is not increased in mildly hyperglycaemic obese diabetic patients. >> 31(1), E24E29 (2008). endobj The lower the percentage of the liver with fatty change indicates that your liver is healthier. 14(2), 8898 (2018). 2014 Apr 28;20(16):4702-11. doi: 10.3748/wjg.v20.i16.4702. Kotronen, A. et al. Endocrinol. Dietary Sodium and Nonalcoholic Fatty Liver Disease: A Systematic Review Intern. A fibrosis score of F2 (7.5 to 10 kPa) indicates moderate scarring that has spread outside the liver. MRE vs Fibroscan: I had a fibroscan - Living with Fatty 39(18), 21332143 (2021). Efficacy of a pedometer-based physical activity program on parameters of diabetes control in type 2 diabetes mellitus. Between September, 2017, and March, 2018, a total of 95 eligible participants (64.40% male) with both T2DM and NAFLD were included, while 32.63% of them were classified as hypermetabolic. NASH=non-alcoholic steatohepatitis. 678.750000 0] /Type /Page Yabiku, K. Efficacy of sodium-glucose cotransporter 2 inhibitors in patients with concurrent type 2 diabetes mellitus and non-alcoholic steatohepatitis: A review of the evidence. Mertens, J. et al. FLF Launches a Public-Private Partnership to Combat the Silent Epidemic of NAFLD, FLF and Fibronostics form a patient education partnership, Echosens Aligns with FLF to Accelerate Screening for Undiagnosed NAFLD and NASH, Fatty Liver Foundation Launches the State of NAFLD/NASH Care in America Initiative to Support Improved Patient Care Experience, FATTY LIVER FOUNDATION TO MARK INTERNATIONAL NASH DAY WITH THREE INTERACTIVE PROGRAMS OFFERING INFORMATION, INSPIRATION, AND SUPPORT FOR PEOPLE AT-RISK OF OR LIVING WITH NAFLD/NASH. According to the results of multivariable logistic regression analyses, hypermetabolism had a positive association with adiponectin (odds ratio [OR] 1.167, 95% confidence interval [CI] 1.0151.342, p=0.030), physical activity (OR 1.134, 95% CI 1.0021.284, p=0.046), alanine transaminase (OR 1.062, 95% CI 1.0061.122, p=0.031) and diastolic blood pressure (OR 1.067, 95% CI 1.0101.127, p=0.021). Triangles represent deciles of participants (n=50) grouped by similar predicted risk. /AIS false Thirdly, the wide availability of FibroScan devices based on VCTE technology, the need for just a serum AST value, its non-invasive nature, its low cost per scan, and its modest requirement to attain technical proficiency required to do the scans, mean the method can be rolled out easily across most clinical practices. *CAP is not available on S probe in all countries. Bril, F. & Cusi, K. Management of nonalcoholic fatty liver disease in patients with type 2 diabetes: A call to action. 34(2), 166170 (2018). There is some evidence suggesting the increased basal metabolic rate (BMR) in subjects with T2DM14,15 and liver diseases16,17. AUROC=area under the receiver operating curve. World J. Gastroenterol. 2022;15(4):360-365. doi: 10.22037/ghfbb.v15i4.2480. have shown that REE increases significantly among adults (33 to 69-year-old) with T2DM in response to the 6-week walking program of 10,000 steps on five or more days of the week70. /CSp /DeviceRGB Nutr. Body composition was estimated by a bioelectrical impedance scale (BC 418 MA, Tanita, Japan). A fibrosis score of F4 ( 14 kPa or higher) means late-stage scarring or cirrhosis, where the scarring is permanent and the damage is irreversible. Drafting of manuscript, A.H. Critical revision, S.K. Diabetes Care 31(1), 128133 (2008). 286(4), F606F616 (2004). 10(10), 10161020 (2002). Controlled attenuation parameter for the detection and quantification of hepatic steatosis in nonalcoholic fatty liver disease. FibroScan measures scarring by measuring the stiffness of your liver. Relationship between blood adipocytokines and resting energy expenditure in young and elderly women. 1 2 . Welle, S. & Nair, K. Relationship of resting metabolic rate to body composition and protein turnover. government site. 2023 Jan 29;15(3):687. doi: 10.3390/nu15030687. A systematic review of literature. Average upper limit normal for CAP is 248. 7) Insulin resistance was estimated using the following formula: HOMA-IR=[Fasting insulin (U/mL)fasting glucose (mmol/L)/22.5]. Nonalcoholic Fatty Liver Disease Increases Cardiovascular Risk in Inflammatory Bowel Diseases. Depending on where you get a FibroScan may determine the scoring system used in your diagnosis. FAST=FibroScan-aspartate aminotransferase. Lombardo, M. et al. 2022 Jul;12(Suppl 1):S26-S36. Type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD) are both progressive health problems worldwide1,2. Clipboard, Search History, and several other advanced features are temporarily unavailable. The results were 4.0 Kpa and CAP score of 179. The median CAP was higher among patients with significant steatosis (317 [IQR 284-339] vs. 250 [227-279] dB/m with <10% steatosis; P < 0.0005) and the AUROC for this outcome was 0.81 (95% CI 0.74-0.88). Am. endobj A.M. Study conception and design, Acquisition of data, Analysis and interpretation of data, Drafting of manuscript, Critical revision, S.M. Finelli, C. & Tarantino, G. What is the role of adiponectin in obesity related non-alcoholic fatty liver disease? Follow the row that has your results. PubMed (B) Calibration plot and calibration intercept and slope. The calibration plot characterises the agreement between observed proportion and predicted probabilities. Publication Paul et al. SAH reports grants from Conatus, Immuron, Second Genome, and Tobira/Allergan; grants and personal fees from Axcella, Cirius, CymaBay, Galmed, Gilead, HightTide, Intercept, NGM, Novartis, Novo Nordisk, Pfizer, Galectin, Genfit, and Madrigal; and personal fees from Metacrine, 3V Bio, Albereo, Alexion, Blade Therapeutics, Bristol-Myers Squibb, Civi BioPharma, CLDF, Contravir, Consynance, Concept, Echosens, Gelesis, HistoIndex, Innovate, IQVIA, Medpace, Perspectum, Poxel, Pometheus, Prometic, Terns, Akero, and Lipocine, outside the submitted work. The performance of the CAP for diagnosing steatosis compared with biopsy was assessed using areas under receiver operating characteristic curves (AUROC). Sport Nutr. Diagnostic performance in the derivation, Diagnostic performance in the derivation cohort of the FAST score for the diagnostic, Calibration plots in external validation, Calibration plots in external validation cohorts (A) French bariatric cohort (n=110). Gastroenterol. BMC Gastroenterol. Critical revision, M.A. Google Scholar. This score will be used by your doctor to grade your steatosis (fatty change). Image, Download Hi-res Investig. Pediatr. Depending upon the reason fatty liver; S1, S2, S3 range differs. Hypertension 43(3), 555560 (2004). 20(3), 23872391 (2020). @Ev*B{p\Qk[Ll0T!]\3# 82(4), 801805 (2005). Am. Physiol. Unauthorized use of these marks is strictly prohibited. CAP (Controlled Attenuation Parameter) is the non-invasive reference parameter used as an aid to diagnose and monitor liver steatosis. PubMed Central Calibration of the score is satisfactory since the intercept is not significantly different from 0, slope is not significantly different from 1, the flexible calibration curve is close to the ideal calibration (solid line), and its CI zone includes the ideal curve. Crit. endobj Transplant 17(2), 216221 (2002). This is usually caused by heart failure. Transient elastography was performed by one experienced operator, using FibroScan 502 instrument (EchoSense, France, 5MHz), to detect and quantify liver steatosis (CAP, dB/m) and fibrosis (LSM, kPa). Echosens and UK National Institute for Health Research. Prevalence of NASH+NAS4+F2=9%. ISSN 2045-2322 (online). 76(1), 133137 (1994). ADS BMC Nephrol. PubMed Calibration plots in external validation cohorts (A) French bariatric cohort (n=110). CAPis available on the three FibroScan probes (S+*, M+ and XL+). The multivariate logistic regression test was used for detecting factors associated with hypermetabolism. 91(4), 16001603 (2006). << This information will help you understand your FibroScan results. Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury. Nutr. There is also evidence showing that resistance training programs increases REE71,72,73,74. 46(2), 325332 (2022). Res. Ravussin, E. et al. PLoS One. The CAP is a promising tool for the noninvasive detection of hepatic steatosis. (Lausanne) 12, 768850 (2021). Plasma adiponectin levels are not associated with fat oxidation in humans. Tarantino, G. et al. Energy expenditure and substrate utilization in older women after strength training: 24-h calorimeter results. Development of alternatives to estimate resting metabolic rate from anthropometric variables in paralympic swimmers. FibroScan is a specialized ultrasound machine for your liver. Moradi, S. et al. Ther Adv Endocrinol Metab. Although there are limitations in applying ALT in the diagnosis of NAFLD and NASH, it is widely used as a surrogate marker of hepatocellular inflammation and damage in liver diseases75, and as it is known, inflammation is significantly related to the elevation of REE76,77. FibroScan is a specialized ultrasound machine to scan your liver to measure fibrosis (scarring) and steatosis (fat accumulation) in the liver. We used FibroScan to detect the incidence of fatty liver and fibrosis in CHB patients, and to assess the correlation of FibroScan measurements with blood chemistry tests. The datasets used and/or analysed during the current study available from the corresponding author on reasonable request. WP%n. $ #B :5AAs/8@lJ(V!GGc\ek5BiPlE~{;D[j1">2D(nPc=/OVE\A6xyQv xolK )E-M CWs]9P];&RL{y^|KnMTB%VO{ipgx;DG_v/@[iKc{39:Gq`%L,OHuNQ Xb+rL~ -9sR^I2= &L-tx\t1tpTj|TT;5Y5xaG>0C(n(\2*ynlXAm3??-q`]e~{Z4 dq`8l^ooA1zWQ,JEBudgdqGVR9J@y@yZG&y~X9 pxJTz|PN(u0[$2cRKm!t(!0COwPjv+WPP%8r Q 137(2), 145155 (2008). Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. FibroScan: What Is It And What To Expect? - Netmeds Waist circumference (WC) was measured at the midpoint between the lower costal margin and the iliac crest. When to Use Pearls/Pitfalls Why Use Age years BMI kg/m Impaired fasting glucose/diabetes No 0 Yes +1 AST U/L ALT U/L Platelet count 10/L Albumin g/dL Result: Please fill out required fields. 2019;16:377386. J. Appl. /F6 6 0 R Do I have Fatty Liver? : r/FattyLiverNAFLD - reddit.com Reddavide, R. et al. An official website of the United States government. Lancet Gastroenterol Hepatol. Dold L, Nielsen MJ, Praktiknjo M, Schwarze-Zander C, Boesecke C, Wasmuth JC, Bischoff J, Rockstroh JK, Karsdal MA, Spengler U, Trebicka J, Strassburg CP, Leeming DJ, Langhans B. BMC Infect Dis. | Clinical and Translational Gastroenterology, 2016. Ciardullo, S. & Perseghin, G. Statin use is associated with lower prevalence of advanced liver fibrosis in patients with type 2 diabetes. Furthermore, our small sample size might have affected the results. The rest of this resource explains your FibroScan results in more detail, including how your healthcare provider uses your results to determine your steatosis grade and fibrosis score. Yanai, H. & Yoshida, H. Beneficical effect of adiponectin on glucose and lipid metabolism and atherosclerothic progression: Mechanisms and perspectives. Noureddin N, Alkhouri N, Brown KA, Noureddin M. Hepatology. Basal metabolic rate in morbidly obese patients with non-alcoholic fatty liver disease. The NFSA score was calculated based on age, hyperglycemia, body mass index, platelets, albumin and serum aminotransferase levels. Diagnostic accuracy of FibroScan-AST score to identify non . The rest of this resource explains your FibroScan results in more detail. Physiol. Liver congestion (when your liver is too full of blood or other fluids). Here are some helpful terms to know related to your FibroScan results: Fibrosis (fy-BROH-sis): Scarring in your liver. | Arq Gastroenterol, 2018. Understanding NAFLD: From Case Identification to Interventions, Outcomes, and Future Perspectives. From diagnosis to treatment, our experts provide the care and support you need, when you need it. The dietary intervention has a positive impact on CAP. The continuous variables with normal distribution were presented as meanstandard deviation (SD) and those with non-normal distribution were presented as median (interquartile range [IQR]). Melby, C. et al. 258(6), E990E998 (1990). doi: 10.1093/crocol/otad004. Shen F, Zheng RD, Mi YQ, Wang XY, Pan Q, Chen GY, Cao HX, Chen ML, Xu L, Chen JN, Cao Y, Zhang RN, Xu LM, Fan JG. QMA was supported by the NIHR Newcastle BRC. Curr. FibroScan has allowed doctors to learn more about the liver without resorting to invasive techniques, which is very efficient for purposes of monitoring. In the present study, an inverse association between FFM and hypermetabolism was shown. Lifestyle modification improves the hepatic steatosis, and CAPcan be used to detect the improvement of hepatic steatosis during follow-up in patients with NAFLD on lifestyle modification. A FibroScan can reveal fatty changes to the liver (steatosis) and scarring. Fasting hyperglycemia predicts lower rates of weight gain by increased energy expenditure and fat oxidation rate. J. To find a location near you with a FibroScan machine, use Echosens locator, which can be found here. CAPis available on the three FibroScan probes (S+*, M+ and XL+). In the present study, the CAP values of the 19 NAFLD patients ranged from 248 to 400 dB/m, with . However, fat free mass was inversely related to hypermetabolism (OR 0.935, 95% CI 0.8830.991, p=0.023). Also, few studies have been designed to determine BMR in subjects with liver disease17. World J. Gastroenterol. FAST=FibroScan-aspartate aminotransferase. Protein turnover is assumed to account for 20% of REE in healthy subjects41, and elevated protein turnover is associated with increased REE42,43 and loss of FFM43. These measurements help your healthcare provider learn more about your liver disease. In patients with NAFLD and T2DM, hypermetabolism has a direct association with adiponectin, physical activity, ALT and diastolic blood pressure, but a diverse relationship with FFM. Alcoholic/Nonalcoholic Fatty Liver Disease Detection with Transient Fibroscan Score Fatty Liver Cap - How To Cure A Fatty Liver (for good eCollection 2023 Jan. Taru MG, Neamti L, Taru V, Procopciuc LM, Procopet B, Lupsor-Platon M. Diagnostics (Basel). /MediaBox [0 0 612 792] PE and ING were supported by the NIHR Nottingham BRC. J. Article Your feedback will help us improve the educational information we provide. JFC reports speaker fees/advisory board fees from EchoSens during the conduct of the study; and personal fees from NovoNordisk, Intercept, and Alnylam, outside the submitted work. FibroScan is an imaging-based diagnostic test developed by Echosens that looks at liver fibrosis (stiffness, scarring) and steatosis (fat) using transient-elastography technology. Kablawi D, Aljohani F, Palumbo CS, Restellini S, Bitton A, Wild G, Afif W, Lakatos PL, Bessissow T, Sebastiani G. Crohns Colitis 360. However, the literature represents diverse findings in regard to adiponectin levels and REE. J. Appl. You can keep reading to learn more about your results. From installation, to training and local support, we provide you with the highest quality of services. There is a silent epidemic of fatty liver disease in the general population, called NAFLD/NASH. Critical revision, R.J. Acquisition of data, S.M.S.J. Estimation of resting energy expenditure considering effects of race and diabetes status. -, Charlton MR, Burns JM, Pedersen RA, Watt KD, Heimbach JK, Dierkhising RA. Univariate logistic regression analysis was used to identify potential variables that have an effect on hypermetabolism. gold standard solution for comprehensive management of liver health, Enhance FibroScan liver disease assessment with biological markers, Your everyday FibroScancompanion free application, Optimize clinical workflows with real-time secure data transmission. PNN reports grants and speaker fees/advisory board fees from Novo Nordisk and Boehringer Ingelheim; speaker fees/advisory board fees from Pfizer, Intercept, Gilead, and Poxel; and grants from Pharmaxis, outside the submitted work. Clin. Can. de Ldinghen V, Vergniol J, Foucher J, Merrouche W, le Bail B. Liver Int. /SM 0.02 CD24 Gene Expression as a Risk Factor for Non-Alcoholic Fatty Liver Disease 90(7), 42164223 (2005). YY reports grants and speaker fees/advisory board fees from Gilead Sciences; and speaker fees/advisory board fees from Bilim la, AbbVie, and Abdi brahim outside the submitted work. References are available in ourbibliography. In the meantime, to ensure continued support, we are displaying the site without styles 16(38), 4773 (2010). x}%q>00 h!h!,B.sGydUHHnno7/??kv=?mT//zI~n?nCOO5g=~|?|onnso1 O6VW/w0vc]!? The fibrosis result is measured in kilopascals (kPa) It is normally between 2 and 6 kPa. Endocrinol. It ranges from 100 to 400 dB/m. Liver biopsy is crucial for selecting patients with non-alcoholic steatohepatitis (NASH) for inclusion in clinical trials and, by implication, for treatment after new drugs are licensed. How to Identify Advanced Fibrosis in Adult Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) Using Ultrasound Elastography-A Review of the Literature and Proposed Multistep Approach. MS, CF, LS, VM, JJD, and PNN were involved in study design and data analysis and data interpretation. A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study. Rodrguez-Iturbe, B. et al. Correction to Lancet Gastroenterol Hepatol 2020; 5: 36273, Statement on offensive historical content, Time between FibroScan and liver biopsy, median (IQR); range, Time between FibroScan and blood analyses, median (IQR); range, Time between liver biopsy and blood analyses, median (IQR); range, Redistribute or republish the final article, Reuse portions or extracts from the article in other works. Gougeon, R. et al. 2012 Jul;32(6):911-8. doi: 10.1111/j.1478-3231.2012.02820.x. I am still having symptoms of right sided pain, nausea, itchy skin and extreme fatigue and light headed. 37(2), 558565 (2018). J. Clin. All authors have read the manuscript and approved the manuscript. The https:// ensures that you are connecting to the FibroScan Detection of Fatty Liver/Liver Fibrosis in 2266 Cases of The prevalence of T2DM among NAFLD and non-alcoholic steatohepatitis (NASH) cases has been reported to be 22.5% and 43.6%, respectively6. NAFLD=non-alcoholic fatty liver disease. Current smoker was attributed to those who had smoked cigarette regularly in the past 6months. If treated early with diet and lifestyle changes, the disease can be reversible. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Agarwal, R. Smoking, oxidative stress and inflammation: Impact on resting energy expenditure in diabetic nephropathy. A score of less than 1.3 may be considered low-risk, while a Fib4 score of more than 3.25 could mean you're at a high risk for liver fibrosis. 318(8), 467472 (1988). J Gastroenterol Hepatol. Tanase, D. M. et al. FibroScan is a type of liver elastography. Correlation between Fibroscan and laboratory tests in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis patients for assessing liver fibrosis 1 Careers. Article Hipskind, P. et al. Hepatology 64(1), 7384 (2016). Physiol. Therap. 4(12), 370373 (1918). BMC Public Health 18(1), 58 (2017). Your doctor will talk with you about your results and give you more information during your appointment. J. Med. In accordance with our findings, Ali et al.63 and Snodgrass et al.64 showed a direct relationship between BMR and blood pressure. Non-alcoholic fatty liver disease is associated with higher metabolic expenditure in overweight and obese subjects: A case-control study.