Avoid or Use Alternate Drug. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. Applies only to oral form of both agents. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Minor/Significance Unknown. Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Applies only to oral form of both agents. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Do Not Copy, Distribute or otherwise Disseminate without express permission. Total dose iron infusion: safety and efficacy in predialysis patients. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. Individual plans may vary Only administer Feraheme as an intravenous infusion over at least 15 minutes and only when personnel and therapies are immediately available for the treatment of anaphylaxis and other hypersensitivity reactions. For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Use Caution/Monitor. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Modify Therapy/Monitor Closely. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Kidney Int. Either increases effects of the other by pharmacodynamic synergism. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count. Applies only to oral form of both agents. Applies only to oral form of both agents. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. The dosage of Venofer is expressed in mg of elemental iron. Fulminant symptoms include confusion, sensation of passing out, paleness. Your doctor will do laboratory tests to monitor your response. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Applies only to oral form of both agents. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. 1974 Jun;31(6):592-5. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Use Caution/Monitor. Applies only to oral form of both agents. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. Each costs about $0.46 to $0.55 per mg of iron. Corrected Sodium and Effective Osmolality. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. . Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Use Caution/Monitor. The dosage of Venofer is expressed in mg of elemental iron. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. You will have to pay for your IV iron. The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. Avoid or Use Alternate Drug. Burns DL, Mascioli EA, Bistrian BR. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. Sodium ferric gluconate (Ferrlecit) 62.5 mg . Separate by at least 4 hours. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. STORAGE: Consult the product instructions and your pharmacist for storage details. Use Caution/Monitor. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. 1. Serious - Use Alternative (1)iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. . Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Do not administer Venofer to patients with iron overload. Give each dose as 15 mg/kg body weight for a total cumulative dose not to exceed 1500 mg of iron per course. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Parenteral iron supplementation. Venofer treatment may be repeated if necessary. Step 2: Calculation and administration of the maximum individual iron dose(s): . Use Caution/Monitor. For liquid medications, also enter the value of the Medicine Concentration and choose . Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. 1988 May;111(5):566-70. 1970; 100(7):301-3. ]Venofer treatment may be repeated if iron deficiency reoccurs. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). Injection site discoloration has been reported following extravasation. Parenteral iron dextran therapy: a review. All you have to do is use the following formula: Liquid\ dose = Dose / Medicine\ concentration Liquid dose = Dose/M edicine concentration. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. Either decreases levels of the other by inhibition of GI absorption. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). This topic . Minor (1)iron sucrose, benazepril. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . Test Dose: Not required. ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. ANNA J. The dosage of Venofer is expressed in mg of elemental iron. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Applies only to oral form of both agents. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Avoid or Use Alternate Drug. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Steps on how to print your input & results: 1. Max Dose. Fill in the calculator/tool with your values and/or your answer choices and press Calculate. Modify Therapy/Monitor Closely. Medically reviewed by Drugs.com. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Dose. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. You can further save the PDF or print it. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. Use Caution/Monitor. J Lab Clin Med; 111(5):566-70. Iron sucrose: 20 mg/mL. This website also contains material copyrighted by 3rd parties. Applies only to oral form of both agents. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Interaction only with oral iron administration. Nutrition. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. Minor/Significance Unknown. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Use Caution/Monitor. vitamin E decreases levels of iron sucrose by increasing hepatic clearance. UpToDate. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. A healthcare provider will give you this injection. Minor/Significance Unknown. Your list will be saved and can be edited at any time. Treatment of anemia due to iron deficiency. Shirley, NY: American Regent, Inc.; 9/2020. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. For additional Safety Information, please see Full Prescribing Information. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. The dosing of Monofer was performed according to the Simplified Table as described in section 4.2 above and dosing of iron sucrose was calculated according to Ganzoni and administered as 200 mg infusions. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Hollands J, Foote E, Rodriguez A. Drug class: Iron products. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. It is unlikely . Minor/Significance Unknown. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose.